David G. Olarsch, N.D.
Naturopathic Doctor
“The doctor of the future will give no medicine, but will interest his patient in the care of the human frame, in diet and in the cause and prevention of disease.”
Thomas A. Edison

Cardiac Px


Price: $39.00

SKU: 1031
Size: 60 Vegi-Caps

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Serving Size: 1 vegetarian capsule
Ingredients per serving:
Magnesium (as Magnesium citrate) 40 mg
Lily of the Valley root 190 mg
Night Blooming Cereus flower 130 mg
Motherwort leaf 80 mg
Hawthorne extract (1.8% Vitexin) 40 mg
Lemon Balm leaf 20 mg

Suggested Use:
1 capsule twice per day. Never exceed more than one capsule in a one hour period or more than 4 capsules in one day.

Drug potentiation can occur with Digoxin.

Should only be taken under the care of a licensed healthcare practitioner.



Overview:

Provides cardiovascular support. For acute heart problems as well as long-term support for chronic heart insufficiency.

Cardiac Px capsules are concentrated herbal capsules providing a higher dose of cardiac herbs which can be used for acute heart problems as well as long-term support for chronic heart insufficiency. This formula is well suited for patients receiving the WT3 protocol.

Another WTSmed professional supplement.



In Depth:
From the WTSmed website:

Health concerns relevant to this product*

Managing WT3 protocol effects
Rapid Heart Rate
Palpitations
Irregular Heart Rhythm
Hyper-functioning thyroid
EKG abnormalities
Slow Heart Rate
Personal History of Heart Problems
Family History of Heart Problems
Nervousness
Anxious Mood

Background Information
Cardiac Px capsules are highly effective in managing a variety of heart problems ranging from chronic heart insufficiency to rapid heart rate. It is also useful in the management of the cardiac irregularities that sometimes occur during the WT3 protocol. Cardiac Px capsules are usually the preferred formula because it is more potent and it is in capsule form. Nevertheless, the capsules are highly concentrated and need to be used with discretion.
It is also important to note that people who exceed recommended dosages with Cardiac Px capsules have a much higher risk of developing potentially serious effects. If you have a patient who you feel might not follow directions carefully it is recommended that they be given a less potent formula.

The Cardiac Px formula contain both fast and slow acting herbs. They appear to be very helpful in a variety of heart conditions, and are perfectly suited for people doing the WT3 protocol. People often notice beneficial effects on palpitations and 'jitters' within 15-30 minutes. Cardiac Px formula can also result in long-term improvements in heart function that can be detected on an echocardiogram. Changes can begin to show within two months of regular use.*

Cardiac Px capsules appear to be helpful in the following complaints: irregular heat rhythm, chronic heart insufficiency, bundle branch problems, EKG abnormalities, fast heart rate, slow heart rate, a history of heart problems, or family history of heart problems. It can also be helpful for people who have heart complaints due to a hyper-functioning thyroid gland.*

Cardiac Px capsules consists of a potent extract of the four primary cardiovascular tonics of western herbalism. Lilly of the Valley (Convallaria majalis) is indicated for use in mitral insufficiency, feeble circulation, chronic heart problems, swollen ankles due to heart problems, irregular heart rhythm, and shortness of breath. It is considered to provide many of the benefits of digitalis without the side-effects (Felter). Hawthorn (Crataegus oxycantha) is considered as one of the best remedies for the heart and circulatory systems (Hoffman). Cactus (Selenicerius grandiflorus) increases the strength of contractions and slows the rate of the heart (Chevallier), and is used to calm heart palpitations from nervousness (Hoffman). Motherwort (Leonurus cardiaca) has demonstrated the ability to decrease rapid heart rate while improving cardiac efficiency. It also reduces anxiousness and nervous tension (Duke).*

Cardiac Px capsules with the WT3 protocol
Most people tolerate the WT3 protocol quite well. There is a chance, however, of cardiovascular irregularities such as increased heart rate, increased awareness of the heartbeat, and palpitations. The Cardiac Px formula has shown the ability to calm increased pulse rates and/or palpitations, which may occasionally accompany the WT3 protocol. They can also calm the nervousness and anxiousness that can sometimes be associated with the WT3 protocol. If people do experience any cardiovascular complaints while on the WT3 protocol there are a few measures that can be taken. They are explained more thoroughly in the Doctor's Manual for Wilson's Temperature Syndrome. They include;

adjusting the T3 dosage*
improving the punctuality of T3 doses*
taking a T4-test dose (involves using a weaker thyroid hormone {T4} to reduce the effects of T3)*
Sometimes these measures are not enough. Occasionally there are people who still have a difficult time tolerating the WT3 protocol. People have reported that Cardiac Px formula has helped them tolerate the WT3 protocol extremely well when they couldn't have tolerated it well without it. Doctors have also reported that Cardiac Px makes it easier to use the protocol because people have fewer cardiovascular complaints. If people on the WT3 protocol start having palpitations they can take a dose of Cardiac Px capsules right then and it will usually diminish the palpitations within a half hour (we also recommend a T4-test dose to stabilize the T3 levels). If people start having cardiovascular complaints their doctors can advise them to try taking Cardiac Px before making a trip to the office. Cardiac Px formulas usually solve the problem.*

In fact, we recommend that all people on the WT3 protocol take Cardiac Px capsules twice a day in an effort to avoid cardiovascular effects in the first place. It's very comforting for people to know that they have something in hand that they can try taking if they start having any complaints.*

If people are experiencing heart rates of over 100 beats per minute Cardiac Px formulas can help.*

To Enable People With Cardiac Risk To Qualify For the WT3 protocol
Some people who want to undergo WT3 protocol have abnormal EKG's, fast heart rates, or a family or personal history of heart problems. WT3 is not advisable for these people unless their heart complaints are normalized. After taking Cardiac Px capsules, many people have found improvements in their EKG's and/or pulse rates so that they were able to do the WT3 protocol. For example, two people wanted to start the WT3 protocol but their resting heart rates were around 103. Both people took one capsule of Cardiac Px per day and their pulse rates decreased to between 70 and 80 bpm within three or four days and stayed there continuously while they were on the WT3 protocol. Of course, Cardiac Px is often useful in many conditions (listed below) even if the patient isn't going to take the WT3 protocol.*

General Tune Up For The Heart
Cardiac Px capsules are not a treatment for cardiac complaints. They contain a collection of herbs that appear to have restorative effects on the function of the heart itself. This is fundamentally different from the effects of most heart medicines. This helps explain how Cardiac Px can be helpful to people with low heart rates as well as people with high heart rates. It also explains how Cardiac Px can help with a variety of heart problems. Most people who benefit from Cardiac Px formulas won't need to take them for life. Most will be able to remain improved even after stopping it completely, or they may only need it very infrequently.*

Chronic heart insufficiency possibly with Chronic Chest Discomfort and/or Fluid Retention
After an episode of chronic heart insufficiency a lot of people can have fluid retention all over their bodies. When the insufficiency is really severe sometimes that swelling never totally goes away. There have been cases in which the fluid went back into the tissues within a week or so just by giving Cardiac Px capsules.*

Irregular heart rhythms
After starting to take Cardiac Px capsules, some people with irregular heat rhythms have been comfortably able to do the WT3 protocol. One patient, finishing her fourth month of the WT3 protocol, had less irregular heat rhythm than before she started. If doctors choose to manage people with irregular heat rhythms, it should be done very carefully. It might be wise to not go higher than about 45 to 52.5mcg of T3 per cycle. Please see the Doctor's Manual for Wilson's Temperature Syndrome. Cardiac Px capsules can be given for one or two weeks before the WT3 protocol is started. It is good to have people come back to the office once a week to check on their progress.*

Cardiac Px formulas appear to provide nutritional substances, adaptive stimulation, and supportive effects for the heart. Some people may benefit from taking Cardiac Px twice a day for life (for example, people with a family history of heart problems). There doesn't seem to be any harm in staying on Cardiac Px in recommended doses. It may actually help people to have stronger hearts.

Cardiac Px capsules should not be taken in doses greater than three capsules a day in divided doses, and not to be used more than once in two hours. These products must be kept away from children.

Side Effects
Cardiac Px capsules are normally very well tolerated within the recommended dosages, and we have had no side effects reported. One of the main active ingredients are cardiac glycosides, which are also found in Digoxin; but the cardiac glycosides in Cardiac PX have a very short half-life compared to Digoxin and have a much lower potential for toxicity. Nevertheless, overdosing on Cardiac Px capsules is potentially very serious. Symptoms of overdose include irregular heat rhythm, high blood pressure, restlessness, confusion, weakness, rapid heart rate, headache, vertigo, and cardiovascular collapse.*

We have been asked at what dose might side effects be noticed. There have not been any reported side effects from the use of Cardiac PX capsules to date. However in the literature we found a case in which one patient took the equivalent of four caps of Cardiac Px capsules and experienced irregular heat rhythm and severe shortness of breath. However, we want to stress that people should never exceed the recommended dosages and that physicians monitor dosage.

Drug Interactions
Drug potentiation with cardiac drugs especially ones that contain cardiac glycosides such as Digoxin should always be considered with both Cardiac Px formulas.

What to Expect
Results can be noticed in as few as 15-30 minutes for acute complaints, and 1-4 weeks for chronic complaints. Response to the product varies by condition and individual.*

Lab Tests
EKG and echocardiogram can be used to assess the impact of the Cardiac PX.

Side Benefits
Cardiovascular health.*


Supporting Research

Lily-of-the-valley
(Convallaria majalis)

Cardiac Function
Lily-of-the-valley herb consists of the dried, above-ground parts of Convallaria majalis L. [Fam. Liliaceae], or closely related species, as well as their preparations in effective dosage. Lily-of-the-valley is recommended for mild cardiac insufficiency, heart insufficiency due to old age, and chronic cor pulmonale, by the German E commision. (1) The primary indication for Convallaria is cardiac debility, when there is evidence of obstruction and congestion, palpitation, arrhythmia, feeble pulse, dyspnea, diminished renal excretion, venous stasis and generalized edema. Convallaria is considered to be positive inotropic on the myocardium, to lower elevated left-ventricular diastolic pressure, as well as to lower pathologically elevated venous pressure.

It is natriuretic and kaliuretic (1). It believed to be safer than digitalis and freer from cumulative effects. (2)

Pharmacology
Convallaria contains a variety of important glycosides, notably the cardioactive convallatoxin. Several other minor glycosides called cardenolides are also present however, such as cheirotoxin, convallarin, convallamarin, convallamarogenin, and convalloside. A variety of saponin glycosides and flavonoid glycosides can also found in the herb, including quercitin and rutin, as well as a volatile oil. Although convallatoxin has marked cardiac properties, the variety of other constituents found in the whole herb appear to modulate its effects. Convallatoxin was found to interact with membrane phospholipids and promote the binding of calcium ions (3). The effect of dietary cardiac glycosides upon blood pressure regulation was investigated in animals fed a synthetic diet. The administration of convallatoxin in the drinking water was shown to delay the onset of the increase in blood pressure observed in the controls. (4).

To Summarize the actions of cardiac glycosides on the heart are:
1. positive inotropic (increasing contractile strength and velocity while delaying relaxation);

2. negative chronotropic (decreasing the time or rate of contraction);

3. negative dromotropic (decreasing stimulus conduction);

4. positive bathmotropic (increasing stimulation of the ventricular muscle).

Contraindications
Therapy with digitalis glycosides and potassium deficiency.
Increased effectiveness and also side effects of simultaneously administered quinidine, calcium, saluretics, laxatives, and extended therapy with glucocorticoids.

References - Lily of the Valley

1. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines Copyright ©1998 American Botanical Council.Published by Integrative Medicine Communications.

2. Felter, HW and JU Lloyd. 1893. King's American Dispensatory. Digitized version available from http://www.ibiblio.org/herbmed/eclectic/kings/main.html.

3. Ivanov LV, Khadzhai IaI, Chueva IN, Makarevich IF.Farmakol. 1987. Effect of cardiac glycosides on the calcium ion binding by biomembrane lipids. Toksikol. Mar-Apr;50(2):30-2.

4. Tamura M, Utsunomiya H, Nakamura M, Landon EJ. 2000. Effect of dietary cardiac glycosides on blood pressure regulation in rats. Can J Physiol Pharmacol Jul;78(7):548-56.


Hawthorne
(Crataegus oxycantha)

Cardiac Function
The berries and flowers of crataegus oxycantha have been used traditionally as cardiac tonics for a variety of heart disorders. Research shows crataegus extracts exert a wide range of positive actions on heart function. Treatment of chronic congestive heart failure stage II, as defined by the New York Heart Association has been studied in a number of clinical trials. In one study, individuals were treated with Hawthorne over a period of eight weeks. Crataegus treatment resulted in improvement in subjective symptoms, such as reduced performance, shortness of breath, and ankle edema.(1) In another study of patients with stage NYHA -II cardiac insufficiency, oral supplementation improved blood pressure, heart rate, and the change in heart rate in response to exercise under standardized bicycle ergometer testing.(2) Clinical data indicates that standardized extracts of Hawthorne increase myocardial performance, improve myocardial circulatory perfusion and tolerance in cases of oxygen deficiency, have antiarrhythmic effects and reduce afterload (3) In a trial without controls involving seven patients with stages II and III cardiac insufficiency, with an angiographically determined left ventricular ejection fraction of less than 55% over a period of 4 weeks, oral administration of 240mg

Hawthorne extract containing daily for 4 weeks increased the ventricular ejection fraction from 29.80 to 40.45%, as measured by angiography.(4).

Hypertension
Crataegus exerts mild blood pressure-lowering activity by dilating coronary vessels, inhibiting angiotensin converting enzyme, acting as an inotropic agent (5). In various animal models, a decrease in peripheral vascular resistance and hypertension occurred after treatment with leaf and/or flower extracts.


References- Hawthorne
1. Weikl A, Assmus KD, Neukum-Schmidt A, et al. Crataegus Special Extract WS 1442. Assessment of objective effectiveness in patients with heart failure. Fortschr Med 1996;114:291-296.

2. Leuchtgens H. Crataegus Special Extract WS 1442 in NYHA II heart failure. A placebo controlled randomized double-blind study. Fortschr Med 1993;111:352-354.

3. Loew D. Crataegus-Spezialextrakte bei Herzinsuffizienz. Gesicherte pharmakologische und klinische Ergebnisse. Der Kassenarzt, 1994, 15:43–52.

4. Weikl A, Noh HS. Der Einfluss von Crataegus bei globaler Herzinsuffizienz. Herz und Gefässe, 1992:516–524.

5. Rewerski VW, Piechocki T, Tyalski M, Lewak S. Some pharmacological properties of oligomeric procyanadin isolated from hawthorn (Crataegus oxyacantha). Arzniem Forsch 1967;17:490-491.


Motherwort
(Leonurus cardiaca)

Cardiac Function
Motherwort is recommended by Commission E for heart palpitations occurring with anxiety attacks or other nervous disorders (1). Studies have demonstrated hypotensive and negatively chronotropic effects on laboratory animals.(2) Extracts of motherwort have direct myocardial actions, inhibiting the effects of calcium chloride and stimulating alpha and beta adrenoceptors (3). Eclectic physicians used motherwort for disturbed sleep, heart palpitations, and high blood pressure. (4)


References - Motherwort
1. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines Copyright © 1998 American Botanical Council. Published by Integrative Medicine Communications

2. Bradley, P.R. (ed.). 1992. British Herbal Compendium, Vol. 1. Bournemouth: British Herbal Medicine Association.

3. Newall, C.A., L.A. Anderson, J.D. Phillipson. 1996. Herbal Medicines: A Guide for Health-Care Professionals. London: The Pharmaceutical Press.

4. Ellingwood, F. 1983. American Materia Medica, Therapeutics and Pharmacognosy. Portland, OR: Eclectic Medical Publications [reprint of 1919 original].


* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
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