David G. Olarsch, N.D.
Naturopathic Doctor
“The doctor of the future will give no medicine, but will interest his patient in the care of the human frame, in diet and in the cause and prevention of disease.”
Thomas A. Edison

Thyroid Px


Price: $0.00

SKU: 1088
Size: 75 Vegi-Caps

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ThyroCare

Price: $0.00
 
Serving Size: 1 vegetarian capsule
Ingredients per serving:
Guggul gum resin~206 mg
Blue Flag root~ (Iris versicolor)206 mg
Ashwaganda root** (Withania sonnifera)75 mg
Nettle herb** (Urtica dioca)75 mg
Bladderwrack Thallus** (Fucus vesiculosis)56 mg
Ginger root** (Zingiber officinale)10 mg
Selenium (methionine)100 mcg
Zinc (citrate)1.65 mg
Iodine (Potassium iodide)4 mg
Seaweed Extract Iodine2 mg
Diiodotyrosine200 mcg
**Certified Organic
~Wildcrafted
Other Ingredients: Magnesium Stearate and Silicone Dioxide as needed.

Suggested Use:
Take 1 capsule twice daily with or without food, or as directed by your health care practitioner. When increasing dose, do so gradually to a maximum dose of 4 capsules twice daily, never to exceed 8 capsules in a 24 hour period, nor to take high doses for longer than 3 months.

Caution: this product can potentiate thyroid hormone replacement medications. Discontinue use if rapid heart rate, palpitations, or skin reactions occur. 1 capsule exceeds the Recommended Daily Allowance for Iodine.

Should only be taken under the care of a licensed healthcare practitioner.



Overview:
Thyroid Px is a very potent blend of nutraceuticals and botanicals that support and restore healthy functioning to the thyroid gland. It is indicated for moderate to severe low thyroid function, autoimmune thyroid dysfunction, Wilson's Temperature Syndrome, chronic fatigue, chronic joint degeneration, and cholesterol problems. Thyroid Px is a stronger thyroid support formula than ThyroCare.*

Another WTSmed professional supplement.



In Depth:
From the WTSmed website:

Health concerns relevant to this product*
Wilson's Temperature Syndrome
Hypo-functioning thyroid
Autoimmune thyroiditis
High cholesterol
Antithyroid antibodies
Thyroid nodules
Swollen Thyroid
Chronic Fatigue
Chronic Joint Degeneration


Supporting Research

Hypothyroidism - Moderate

Overview
Guggul (Commiphora mukul) is considered a rejuvenating herb and stimulant in Ayurvedic medicine. The resin of the Commiphora mukul tree, termed "guggul" or "guggulipid", has been associated with thyroid stimulating activity. Guggul causes the thyroid to increase iodine uptake and increase production of thyroid hormones. Studies in both animals and humans have shown that guggul can also modulate cholesterol levels. Fucus, also known as bladderwrack or kelp, has been a traditional remedy for thyroid problems for thousands of years, and it appears to provide it with the nutrition and substrates the thyroid gland requires. People living near oceans or seas have a historically low rate of hypothyroidism, due, in part, to ingestion of iodine-rich food, such as seafood and seaweeds like bladderwrack. Iris versicolor (Blue Flag) has traditionally been used to improve thyroid function with both hypofunctioning and hyperfunctioning thyroid patients. It appears to act as a potent detoxifier of the thyroid gland, which is particularly susceptible to disruption from environmental toxins.

Thyroid Supporting Herbs and Nutrients
Guggul stimulates the thyroid to increase iodine uptake and increase production of thyroid hormones. Studies in both animal models and humans have shown that guggul can also balance cholesterol levels. Iris versicolor (Blue Flag) is a potent detoxifier of the thyroid gland, which is particularly susceptible to disruption from environmental toxins. Fucus, or bladderwrack (kelp), is known to prevent hypothyroidism in coastal areas. Iodine, in the form of organic iodine (extracted from seaweed) and potassium iodide, are added to approach the Japanese mainland consumption of an estimated 13.8 mg per day. Diiodotyrosine is a molecular precursor to the thyroid hormones T4 and T3. Selenium supplementation reduced thyroid antibodies (TPOAb) by 40% in three months in a blinded controlled prospective study in female patients with autoimmune thyroiditis. Selenium is also a cofactor for type I hepatic 5'-deiodinase, the enzyme that converts T4 to the more active T3, and degrades rT3. Zinc deficiency in animal experiments resulted in a 30% decrease in levels of serum T3 with a corresponding decrease in the activity of type I 5'-deiodinase of 67%. In humans, zinc supplementation reestablished normal thyroid function in hypothyroid patients treated with anticonvulsants.


References
1. Blumenthal ed. German E Commision Monograph: Commiphora mukul. American Botanical Council, 2000.

2. Tripathy, Y.B., Malhotra, O.P.and Tripathy, S.N (1985) Thyroid-stimulating actions of (Z)guggulsterone obtained from Commiphora mukul. Planta Medica. 78-80.

3. Suzuki, H, Higuchi T, Sawa, K, Ohtaki, S, Tolli , J 1965. Endemic coast goitre in Hokkaido, Japan. Acta Endocr. 50 : 161-176.

4. Japanese Ministry of Health.

5. Gartner R, Gasnier BC, Dietrich JW, Krebs B, Angstwurm MW Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations. Clin Endocrinol Metab 2002 Apr;87(4):1687-91.

6. Fujimoto S, Indo Y, Higashi A, et al. Conversion of thyroxine into tri-iodothyronine in zinc deficient rat liver. J Pediatr Gastroenterol Nutr 1986;5:799-805.

Nishiyama S, Futagoishi-Suginohara Y, Matsukura M, et al. Zinc supplementation alters thyroid hormone metabolism in disabled patients with zinc deficiency. J Am Coll Nutr 1994;13:62-67.

Guggul
(Comiphora mukul)

Background
The resin of the Commiphora mukul tree, known as myrrh, has been used in Ayurvedic medicine for more than 2000 years to treat a variety of ailments, including mouth ulcers, gingivitis, pharyngitis, as well as respiratory catarrh. For stomatitis (inflammation of the mouth), it is combined with honey and rectified spirit, then dissolved in rose petal infusion, and taken as a mouthwash. (1)

Thyroid
The resin of the Commiphora mukul tree, termed "guggul" or "guggulipid", was known to can cause weight loss. This has been associated with the thyroid stimulating activity of guggulsterone Z, causing the thyroid to increase iodine uptake and increase production of thyroid hormones. (2) Enhanced thyroid hormone synthesis from guggul use was also associated with increased tissue oxygen uptakes in the liver and muscle. (3)

Hyperlipidemia
Studies in both animal models and humans have shown that guggul can decrease elevated lipid levels.

Guggul was approved by the government of India in 1987 for the treatment of hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia. Several well-designed clinical trials using various extracts of guggul have reported significant lowering of triglycerides, total cholesterol, total serum lipids, low density lipoprotein-C, as well as significant increases in high density lipoprotein-C. (4) No serious adverse reactions have been reported.Gugulipid has demonstrated equivalent efficacy to clofibrate in clinical trials for the treatment of hyperlipidemia.(5). The lipid lowering effects continue after discontinuation of therapy and has been reported in a range of 6 to20 weeks to return time to baseline lipid profile (6).

Pharmacology
The stereoisomers E- and Z-guggulsterone have been identified as the active agents in this resin. Recent studies have shown that these compounds are antagonist ligands for the bile acid receptor farnesoid X receptor (FXR), which regulates bile acid production in the liver. Since the principal means of cholesterol elimination is through bile excretion, it is likely that this effect accounts for the hypolipidemic activity of these phytosteroids. (6)


References- Guggul
1. Blumenthal ed. German E Commision Monograph: Commiphora mukul. American Botanical Council, 2000

2. Tripathy, Y.B., Malhotra, O.P.and Tripathy, S.N (1985) Thyroid-stimulating actions of (Z)guggulsterone obtained from Commiphora mukul. Planta Medica. 78-80.

3. Tripathy, Y.B., Tripathy, P., Malhotra, O.P.and Tripathy, S.N. (1988) Thyroid stimulating action of (Z) guggulsterone. Mechanism of action. Planta Medica 271-276.

4. Singh RB, Niaz MA & Ghosh S: Hypolipidemic and antioxidant effects of commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc Drugs Ther 1994; 8(4):659-664.

Singh RP, Singh R, Ram P et al: Use of Pushkar-guggul, an indigenous antiischemic combination, in the management of ischemic heart disease. Int J Pharmacog 1993; 31(2):147- 160.

5. Nityanand S, Srivastava JS & Asthana OP: Clinical trials with gugulipid--a new hypolipidaemic agent. J Assoc Physicians India 1989; 37(5):323-328.

6. Nancy L. Urizar and David D. Moore; Guggulipid: A Natural Cholesterol-Lowering Agent Annual Review of Nutrition.Vol. 23: 303-313 July 2003.

Bladderwrack
(Fucus vesiculosis)

Background
Bladderwrack is a seaweed found attached to rocks along the coasts of the North Atlantic ocean; it occurs as a flat, mucilaginous, olive brown thallus with spherical air vesicles. It grows on the northern Atlantic and Pacific coasts of the United States and on the northern Atlantic coast and Baltic coast of Europe. The main stem of bladderwrack, known as the thallus, is used medicinally. The thallus has tough, air-filled pods or bladders to help the algae float--thus the name bladderwrack. Although bladderwrack is sometimes called kelp, that name is not specific to this species.

Thyroid
The last national nutritional survey (NHANES III 1988-1994) revealed that 15% of the U.S. adult female population are iodine-deficient, as defined by the World Health Organization: levels of iodine/iodide (I) excretion below 50 ug/L (x). Goiter rates in the US have been reduced by the addition of iodide to table salt. Nevertheless, in certain high risk areas goiter is still relatively common (5-6%). This may be due in part to the consumption of certain foods, known as goitrogens, that block iodine utilization, combined with salt avoidance, low soil iodine levels, and lack of seafood and seaweed consumption. Goitrogens include turnips,cabbage, mustard,cassava root, soybeans, peanuts, pine nuts and millet.(2) Mainland Japanese women have a very low incidence and prevalence of fibrocystic breast disease and breast cancer, and some investigators have proposed that high iodine consumption the protective factor. According to the Japanese Ministry of Health, the average daily I intake in mainland Japanese is 13.8 mg. It has also been known for some time that people living near oceans or seas have a historically low rate of hypothyroidism, due to ingestion of iodine-rich foods. Badderwrack contains as much as 600mcg of iodine per gram (3) and has been traditionally used for treating thyroid goiter and obesity (4). In addition, a number of seaweeds have been found to contain diiodotyrosine (DIT) in small amounts (5). In the thyroid gland, thyroxine (T4) is created by the coupling of two DIT molecules. Also within the thyroid one molecule of DIT can condense with monoiodotyrosine (MIT) to form either T3 or rT3.

Fibrocystic Breast Disease
Absence of iodine in the breast tissue appears to make the epithelium more sensitive to estrogen stimulation. Thus increased sensitivity can produce excess secretions which cause the breast to distend and produce small cysts and eventually fibrosis. A number of studies have shown that both iodide and iodine is effective in about 70% of patients (7). However, significant side effects were found to be much less common with elemental iodine versus iodide. Iodide was associated with altered thyroid function (4%) and acne (15%). Therefore, organic sources of iodine, such as Bladderwrack and kelp, are preferred to inorganic iodides (potassium iodide, sodium iodide etc).

Cautions
Bladderwrack can concentrate industrial heavy metals so should be collected only in areas of relatively unpolluted waters.

References - Bladderwrack
1. Hollowell J., Staehling N., Hannon W., Flanders D., Gunter E., Maberly G., Iodine Nutrition in the United States. (1971-1974 and 1988-1994) J. Clinical Endocrinology and Metabolism, 83:3401-3408, 1998.

2. Murray, M. Encyclopedia of Nutritional Supplements. Prima Pub 1996 pg205

3. McGuffin M et al. American Herbal Products Association Botanical Safety Handbook. CRC press, FL.

4. Suzuki, H, Higuchi T, Sawa, K, Ohtaki, S, Tolli , J 1965. Endemic coast goitre in Hokkaido, Japan. Acta Endocr. 50 : 161-176.

5. POHLOUDEK-FABINI R, KATTERBACH HA. Y Pharmazie. 1965 Mar;20:176. ON THE PRESENCE OF DIIODOTYROSINE IN BALTIC SEA FUCUS.

6. Ball SG, Sokolov J, Chin W. 3,5-Diiodo-Lthyronine (T2) has selective thyromimetic effects in vivo and in vitro. J Mol Endocrinol 1997;19:137-147.

7. Ghent W, et al. Iodine replacement in fibrocystic disease of the breast. Can J Surg 36, 453-460, 1993.


* These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.
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